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Plexera Inc spr data analysis module software
Spr Data Analysis Module Software, supplied by Plexera Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/spr+analysis/analysis+data+module/us12656342-506-14-13
Average 86 stars, based on 1 article reviews
spr data analysis module software - by Bioz Stars, 2026-10
86/100 stars

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Article Title: Structural Optimization of Marine Natural Product Pretrichodermamide B for the Treatment of Colon Cancer by Targeting the JAK/STAT3 Signaling Pathway.
Article Snippet: To obtain the equilibrium dissociation constant (KD), these responses were fit to a 1:1 Langmuir binding model by PLEXERA SPR Date Analysis Module (DAM) software program.

Article Title: Screening and optimization of shark nanobodies against SARS-CoV-2 Spike RBD.
Article Snippet: 20 SARS-CoV-2 continues to threaten human health, antibody therapy is one way to 21 control the infection.. Because new SARS-CoV-2 mutations are constantly emerging, 22 there is an urgent need to develop broadly neutralizing antibodies to block the viral 23 entry into host cells.. VNAR from sharks is the smallest natural antigen binding 24 Jo urn al Pr e-p roo f

Article Title: Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives.
Article Snippet: Development of allosteric inhibitors may be a viable strategy to discover hypoglycemic drugs targeting PTP1B.. Allosteric inhibitors occupying the BB site that is a hydrophobic pocket restrict the WPD loop in an open conformation, preventing the physiological dephosphorylation reaction.. Toward the BB site, sixty bromocatechol-chalcone derivatives were designed and synthesized as allosteric inhibitors of PTP1B against diabetes mellitus.

Binding Assay:

Article Title: FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure.
Article Snippet: .. Subsequently, the regeneration buffer as flowed at 2 μL min− 1 for 200 s. All binding parameters ere recorded and processed using the manufacturer’s SPR data nalysis platform (Plexera SPR Data Analysis Module). ..

Article Title: Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P
Article Snippet: .. The binding results were collected and analyzed by Plexera SPR Data Analysis software and GraphPad Prism 10. ..

Article Title: Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Article Snippet: Article Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics

Article Title: Daidzin protects against dengue virus infection by targeting viral envelope protein
Article Snippet: .. The data was analyzed using Plexera SPR data analysis module, and binding affinity curve and the equilibrium dissociation constant (KD) were generated using BIAevaluation software. ..

SPR Assay:

Article Title: FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure.
Article Snippet: .. Subsequently, the regeneration buffer as flowed at 2 μL min− 1 for 200 s. All binding parameters ere recorded and processed using the manufacturer’s SPR data nalysis platform (Plexera SPR Data Analysis Module). ..

Article Title: Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P
Article Snippet: .. The binding results were collected and analyzed by Plexera SPR Data Analysis software and GraphPad Prism 10. ..

Article Title: Adaptation of NAPPA for surface plasmon resonance imaging analyses
Article Snippet: .. Regions-of-interest in the AVI video format were first identified and analyzed with the Plexera SPR Data Analysis Module software. ..

Article Title: Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Article Snippet: Article Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics

Article Title: Daidzin protects against dengue virus infection by targeting viral envelope protein
Article Snippet: .. The data was analyzed using Plexera SPR data analysis module, and binding affinity curve and the equilibrium dissociation constant (KD) were generated using BIAevaluation software. ..

Software:

Article Title: Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P
Article Snippet: .. The binding results were collected and analyzed by Plexera SPR Data Analysis software and GraphPad Prism 10. ..

Article Title: Adaptation of NAPPA for surface plasmon resonance imaging analyses
Article Snippet: .. Regions-of-interest in the AVI video format were first identified and analyzed with the Plexera SPR Data Analysis Module software. ..

Article Title: Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Article Snippet: Article Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics

Article Title: Daidzin protects against dengue virus infection by targeting viral envelope protein
Article Snippet: .. The data was analyzed using Plexera SPR data analysis module, and binding affinity curve and the equilibrium dissociation constant (KD) were generated using BIAevaluation software. ..

Generated:

Article Title: Daidzin protects against dengue virus infection by targeting viral envelope protein
Article Snippet: .. The data was analyzed using Plexera SPR data analysis module, and binding affinity curve and the equilibrium dissociation constant (KD) were generated using BIAevaluation software. ..



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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore <t>T200.</t> (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.
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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore <t>T200.</t> (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.
Spr Data Analysis Module Software, supplied by Plexera Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore <t>T200.</t> (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.
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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore <t>T200.</t> (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.
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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore <t>T200.</t> (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.
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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore <t>T200.</t> (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.
Spr Analysis, supplied by Biacore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore T200. (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.

Journal: Advanced Science

Article Title: Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

doi: 10.1002/advs.78117

Figure Lengend Snippet: Highly malignant CRC is more sensitive to bortezomib. (A) The relation between GJB2 expression and IC 50 values of BTZ in CRC cells was analyzed by GDSC. (B) The protein levels of Cx26 and Tubulin in SW480‐NC and SW480‐OE‐Cx26 cells were detected by western blot. Tubulin was used as a loading control. The IC 50 values of BTZ in SW480‐NC and SW480‐OE‐Cx26 cells were measured by MTT assay. *** p < 0.001 vs . Control; by unpaired student's t ‐test (mean ± SEM). (C) Molecular docking analysis of BTZ and PIMT via Discovery Studio. On the right is the 2D diagram of the interaction between BTZ and amino acid residues of PIMT. (D) PIMT was incubated with DMSO, BTZ (0.01, 0.1, 1 µM), and SAH (1 µM), respectively, delta Tm was calculated compared to the DMSO group. Data are presented as mean ± SEM of at least three replicates. (E) Dose‐response curves for a gradient dilution of BTZ binding to PIMT were measured by Biacore T200. (F) PIMT activity was determined using a methyltransferase activity assay kit. ** p < 0.01 vs . DMSO; by one‐way ANOVA followed by Dunnett's multiple comparisons test (mean ± SEM). (G) The IC 50 values of BTZ in SW620‐shRNA‐NC and SW620‐shRNA‐PIMT cells were measured by MTT assay. Data are presented as the mean ± SEM of three replicates.

Article Snippet: The Biacore T200 molecular interaction analysis system (GE Healthcare, Uppsala, Sweden) was used to measure the change in response value when the gradient concentration of BTZ solution flowed through the chip, and the kinetic constant of the interaction between small molecules and proteins was obtained.

Techniques: Expressing, Western Blot, Control, MTT Assay, Docking Assay, Analysis, Incubation, Binding Assay, Activity Assay, shRNA